How much is a ticket from Mayaguez to Panama City?

Depending on when you travel and how far in advance you book, fares between Mayaguez and Panama City can differ a lot.

Choose a date to explore the best fares now.

If you’re flexible with timing, consider overnight flights — they often cost less and are less crowded. Exploring multiple date and time combinations can help you find the cheapest solution.

Planning flights between Mayaguez and Panama City? Don’t forget the airport options

Especially when flying to medium or large cities, it's worth checking all possible airport combinations before booking.

• Airports in Mayaguez: Mayaguez - Eugenio Maria de Hostos is the only airport in this city.
• Airports in Panama City: Panama City features 2 airports - Pacífico International Airport, Paitilla.

Check for differences in transport costs to and from each airport — they affect your total spend. Choosing the right airport can make a real difference in price and timing.

Find the best flight from Mayaguez to Panama City

With Jetcost, you can filter results by flight time, airline, price range, and layovers. Choose direct or connecting flights, round-trip or one-way, and compare offers from the best airlines and travel agencies.

Other popular destinations

Searching for flights to Panama? Travelers also looked at: Bocas Del Toro, Changuinola, David, Panama City, Puerto Obaldia.

Use filters to exclude options that don’t match your budget or travel preferences and personalize your search for Mayaguez – Panama City flights.